abstract：OBJECTIVE:Only two-thirds of depressive patients respond to antidepressant treatment. In recent years, addition of an atypical antipsychotic drug to ongoing treatment with an antidepressant has been considered effective and well-tolerated. In the present study, we compared the efficacy between paroxetine and sertraline...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yoshimura R,Kishi T,Hori H,Ikenouchi-Sugita A,Katsuki A,Umene-Nakano W,Iwata N,Nakamura J

更新日期：2012-12-03 00:00:00

abstract：:Accumulating evidence supports the hypothesis that modulation of glutamatergic system via NMDA receptors and mGlu5 receptors might be an effective antidepressant therapy. However, clinical application of NMDA and mGlu5 antagonists in the therapy of depression is still an open question. In the present study we investig...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pałucha-Poniewiera A,Pilc A

更新日期：2012-10-01 00:00:00

abstract：:Sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, has recently been reported to affect convulsant activity in some animal models of seizures and epilepsy. Moreover, its influence on the protective activity of some antiepileptic drugs (AEDs) was also noted. The aim of the present study was to investigate th...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Nieoczym D,Socała K,Luszczki JJ,Czuczwar SJ,Wlaź P

更新日期：2012-10-01 00:00:00

abstract：:Several studies have shown that the α₁-adrenoreceptor is involved in controlling extracellular serotonin levels. The administration of the α₁-adrenoreceptor antagonist prazosin was shown to decrease extracellular serotonin levels in the hippocampus, the prefrontal cortex and the raphe nucleus, while the administration...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Takamura N,Masuda T,Inoue T,Nakagawa S,Koyama T

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:The use of clozapine or other second generation antipsychotics (SGAs) has been reported to produce obsessive compulsive (OC) symptoms as adverse mental affects. However, it is not yet clear if SGA-induced OC symptoms have the same phenomenological characteristics as those displayed in obsessive compulsive dis...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kim JH,Ryu S,Nam HJ,Lim M,Baek JH,Joo YH,Kwon JS,Ha TH,Hong KS

更新日期：2012-10-01 00:00:00

abstract：:Supratherapeutic doses of the analgesic acetaminophen (paracetomol) are reported to promote social behavior in Swiss mice. However, we hypothesized that it might not promote sociability in other strains due to cannabinoid CB(1) receptor-mediated inhibition of serotonin (5-HT) transmission in the frontal cortex. We exa...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gould GG,Seillier A,Weiss G,Giuffrida A,Burke TF,Hensler JG,Rock C,Tristan A,McMahon LR,Salazar A,O'Connor JC,Satsangi N,Satsangi RK,Gu TT,Treat K,Smolik C,Schultz ST

更新日期：2012-08-07 00:00:00

abstract：OBJECTIVE:Previous studies have indicated that the immune may be involved in the pathogenesis of tardive dyskinesia (TD). Some genetic polymorphisms in the human leukocyte antigen (HLA) I and II regions have been associated with TD, and the tumor necrosis factor-α (TNF-α) gene is located in the HLA III region. TNF-α le...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wang F,Fan H,Sun H,Yang F,Luo Y,Liu H,Kosten TR,Lu L,Zhang XY

更新日期：2012-04-27 00:00:00

abstract：:Although the memory deficits produced by pre-training benzodiazepines administration have been extensively demonstrated both in humans and in animal studies, there is considerable controversy about the involvement of the state-dependency phenomenon on benzodiazepines-induced anterograde amnesia. The present study aime...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sanday L,Zanin KA,Patti CL,Tufik S,Frussa-Filho R

更新日期：2012-04-27 00:00:00

abstract：OBJECTIVE:Bipolar disorder is associated with a high risk of suicide. Many clinical characteristics and, recently, biomarkers have been studied with the aim to find useful predictors of suicidality. The role of serum lipids has also been explored albeit with conflicting results; however, few studies have been focused o...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： D'Ambrosio V,Salvi V,Bogetto F,Maina G

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:The high use of long-term benzodiazepines (BZDs) with second-generation antipsychotics (SGAs) has been identified as an important issue in the treatment of schizophrenia in Japan. The aim of this study was to evaluate the effects of gradual reduction or discontinuation of daytime BZD use on cognitive functio...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kitajima R,Miyamoto S,Tenjin T,Ojima K,Ogino S,Miyake N,Fujiwara K,Funamoto Y,Arai J,Tsukahara S,Ito Y,Tadokoro M,Anai K,Kaneda Y,Yamaguchi N

更新日期：2012-03-30 00:00:00

abstract：:The neurotoxicity of antipsychotic (AP) drugs seems to be linked with neurological side effects like extrapyramidal symptoms (EPS). On the other hand, neuroprotective effects can mitigate or slow the progressive degenerative structural changes in the brain leading to improved outcome of schizophrenia. First and second...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gassó P,Mas S,Molina O,Bernardo M,Lafuente A,Parellada E

更新日期：2012-01-10 00:00:00

abstract：:Excessive free radical production or oxidative stress may be involved in the pathophysiology of schizophrenia as evidenced by increased superoxide dismutase (SOD) activities, a critical enzyme in the detoxification of superoxide radicals. This study compared plasma SOD activities in 78 never-medicated first-episode an...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wu Z,Zhang XY,Wang H,Tang W,Xia Y,Zhang F,Liu J,Fu Y,Hu J,Chen Y,Liu L,Chen DC,Xiu MH,Kosten TR,He J

更新日期：2012-01-10 00:00:00

abstract：:Cocaine use disorders are an unrelenting public health concern. Behavioral treatments reduce cocaine use by providing non-drug alternative reinforcers. The purpose of this human laboratory experiment was to determine how response cost for non-drug alternative reinforcers influenced cocaine choice. Seven cocaine-using,...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Stoops WW,Lile JA,Glaser PE,Hays LR,Rush CR

更新日期：2012-01-10 00:00:00

abstract：:Gender differences in various clinical features of schizophrenia have been noted and estrogen has been regarded to play important roles. A few previous studies on the association between estrogen receptor (ER) genotypes and schizophrenia focused mainly on ER α gene but failed to report consistent results. The present ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Min JA,Kim JJ,Pae CU,Kim KH,Lee CU,Lee C,Paik IH

更新日期：2012-01-10 00:00:00

abstract：:Physical exercise protocols have varied widely across studies raising the question of whether there is an optimal intensity, duration and frequency that would produce maximal benefits in attenuating symptoms related to anxiety disorders. Although physical exercise causes modifications in neurotransmission systems, the...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Costa MS,Ardais AP,Fioreze GT,Mioranzza S,Botton PH,Portela LV,Souza DO,Porciúncula LO

更新日期：2012-01-10 00:00:00

abstract：:The clinical efficacy of aripiprazole in the treatment of psychosis relies on a partial agonism at D2 receptors. As the expression of this receptor differs physiologically between pre- and post-synaptic sites and is affected by pathological conditions or pharmacological treatments, it appears difficult to predict the ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Koener B,Focant MC,Bosier B,Maloteaux JM,Hermans E

更新日期：2012-01-10 00:00:00

abstract：OBJECTIVE:Posttraumatic stress disorder (PTSD) is associated with abnormal information processing. The P300 component of event-related potentials (ERPs) is known to be a useful marker of information processing. The purposes of this study were to determine the P300 current source density in PTSD patients, and its relati...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bae KY,Kim DW,Im CH,Lee SH

更新日期：2011-12-01 00:00:00

abstract：:The serotonin transporter gene promoter region polymorphism (5-HTTLPR) has been linked to psychiatric disorders, mostly anxiety and affective disorders. In elderly populations 5-HTTLPR polymorphism has also been reported to be associated with serum lipid levels. We have examined the interaction of the 5-HTTLPR polymor...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tomson K,Merenäkk L,Loit HM,Mäestu J,Harro J

更新日期：2011-12-01 00:00:00

abstract：:Among drugs that act on serotonergic neurotransmission, selective serotonin (5-HT) reuptake inhibitors (SSRIs) are now the gold standard for the treatment of anxiety disorders. The precise mechanisms of the anxiolytic actions of SSRIs are unclear. We reviewed the literature related to the effects of SSRIs and the neur...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Inoue T,Kitaichi Y,Koyama T

更新日期：2011-12-01 00:00:00

abstract：RATIONALE:Treatment guidelines for major depressive disorder (MDD) recommend a continuous use of antidepressants for several weeks, while recent meta-analyses indicate that antidepressant efficacy starts to appear within 2 weeks and early treatment nonresponse is a predictor of subsequent nonresponse. OBJECTIVES:We pr...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Nakajima S,Uchida H,Suzuki T,Watanabe K,Hirano J,Yagihashi T,Takeuchi H,Abe T,Kashima H,Mimura M

更新日期：2011-12-01 00:00:00

abstract：:Recent brain imaging studies have shed light on understanding the pathogenesis of mood disorders. Evidence of structural, chemical, and functional brain changes, particularly in prefrontal cortex, cingulate, and amygdala, has been revealed in major depressive disorder (MDD). Furthermore, imaging techniques have been a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bellani M,Dusi N,Yeh PH,Soares JC,Brambilla P

更新日期：2011-08-15 00:00:00

abstract：:Bipolar II depression is a serious and disabling illness associated with significant impairment and high rates of suicide attempts. However, mechanisms underlying emotional dysregulation in this condition are poorly characterized. The goal of this work was to investigate one component of emotional processing in this d...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Marchand WR,Lee JN,Garn C,Thatcher J,Gale P,Kreitschitz S,Johnson S,Wood N

更新日期：2011-08-15 00:00:00

abstract：:Ca(2+)-dependent activator protein for secretion 2 (CADPS2), a secretory granule associate protein, mediates monoamine transmission and the release of neurotrophins including brain-derived neurotrophic factor (BDNF) which have been implicated in psychiatric disorders. Furthermore, the expression of CADPS2deltaExon3, a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hattori K,Tanaka H,Wakabayashi C,Yamamoto N,Uchiyama H,Teraishi T,Hori H,Arima K,Kunugi H

更新日期：2011-08-15 00:00:00

abstract：:Electroconvulsive therapy (ECT) is an effective treatment alternative for schizophrenia. Previous studies have already indicated the possible effects of oxidative stress in this disorder. However, there have been no previous studies evaluating the effects of ECT on the oxidative stress in these patients. We therefore ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kartalci S,Karabulut AB,Ozcan AC,Porgali E,Unal S

更新日期：2011-08-15 00:00:00

abstract：:Due to global industrialization, the light cycle is shifting to longer daytime. Mounting evidence indicates that social developmental disorders may correlate with longer periods of daytime in childhood. However, the exact mechanisms of this link remain unclear. To examine the impact of longer day-time on psychosocial ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Senoo A,Okuya T,Sugiura Y,Mimura K,Honda Y,Tanaka I,Kodama T,Tokuno H,Yui K,Nakamura S,Usui S,Koshiba M

更新日期：2011-08-01 00:00:00

abstract：:The study of the causes and mechanisms underlying psychiatric disorders requires the use of non-human models for the test of scientific hypotheses as well as for use in pre-clinical drug screening and discovery. This review argues in favor of the use of zebrafish as a novel animal model to study the impact of early (s...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Steenbergen PJ,Richardson MK,Champagne DL

更新日期：2011-08-01 00:00:00

abstract：:Identifying the genetic and neurobiological mechanisms underlying certain behavioural traits is an important strategy to understand the aetiology of various psychiatric disorders and to find potential new treatment possibilities. It has proven a great challenge to develop paradigms that allow translational research fo...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： de Mooij-van Malsen AJ,Vinkers CH,Peterse DP,Olivier B,Kas MJ

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to examine the relationships between glycogen synthase 3β gene polymorphisms and bipolar I disorder, manic in a Korean sample. METHODS:Patients with bipolar disorder (n=118) and a control group (n=158) were assessed by genotyping for GSK3β single nucleotide polymorphisms (SNPs) -172...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lee YJ,Kim YK

更新日期：2011-07-01 00:00:00

abstract：:Recently developed mouse models have implicated the vesicular glutamate transporter 2 (VGLUT2) in psychostimulant-induced hyperactivity, a behavioral assay that is often applied to evaluate mouse behavior related to positive schizophrenia (SCZ) symptomatology. In present research, we wanted to evaluate further the rol...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Naert A,Callaerts-Vegh Z,Moechars D,Meert T,D'Hooge R

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Using a newly developed regional homogeneity (ReHo) approach, we were to explore the features of brain activity in patients with treatment-resistant depression (TRD) in resting state, and further to examine the relationship between abnormal brain activity in TRD patients and specific symptom factors derived ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Guo WB,Sun XL,Liu L,Xu Q,Wu RR,Liu ZN,Tan CL,Chen HF,Zhao JP

更新日期：2011-07-01 00:00:00

abstract：:Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs. Although benzodiazepines improve sleep, their multiple adverse effects hamper their application. Adverse effects include impairment of memory and cognitive functions, next-day hangover and d...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Srinivasan V,Brzezinski A,Pandi-Perumal SR,Spence DW,Cardinali DP,Brown GM

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Major depressive disorder (MDD) is associated with abnormalities in the recognition of emotional stimuli. MDD patients ascribe more negative emotion but also less positive emotion to facial expressions, suggesting blunted responsiveness to positive emotional stimuli. To ascertain whether these emotional biase...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Péron J,El Tamer S,Grandjean D,Leray E,Travers D,Drapier D,Vérin M,Millet B

更新日期：2011-06-01 00:00:00

abstract：:The concept of negative symptoms in methamphetamine (MA) psychosis (e.g., poverty of speech, flatten affect, and loss of drive) is still uncertain. This study aimed to use differential item functioning (DIF) statistical techniques to differentiate the severity of psychotic symptoms between MA psychotic and schizophren...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Srisurapanont M,Arunpongpaisal S,Wada K,Marsden J,Ali R,Kongsakon R

更新日期：2011-06-01 00:00:00

abstract：:Enhancement of neurocognition is essential in the treatment of schizophrenia. In our previously reported six-week randomized controlled trial (RCT) mirtazapine added to conventional antipsychotics improved not only negative, but also positive symptoms and neurocognition in difficult-to-treat schizophrenia. The present...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Stenberg JH,Terevnikov V,Joffe M,Tiihonen J,Tchoukhine E,Burkin M,Joffe G

更新日期：2011-06-01 00:00:00

abstract：:A great number of clinical observations show a relationship between epilepsy and depression. Idiopathic generalized epilepsy, including absence epilepsy, has a genetic basis. The review provides evidence that WAG/Rij rats can be regarded as a valid genetic animal model of absence epilepsy with comorbidity of depressio...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sarkisova K,van Luijtelaar G

更新日期：2011-06-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration with unclear etiology and no effective treatment to date. ALS is, however, increasingly recognized as a multisystem disorder associated with impaired cognition. The overlap between ALS and dementia at clinical, genetic and neuropathol...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Liscic RM,Breljak D

更新日期：2011-03-30 00:00:00

abstract：:Associations between attention deficit hyperactivity disorder (ADHD) and genetic polymorphisms in the dopamine receptors, transporter and metabolizing enzymes have been reported in different ethnic groups. Gene variants may affect disease outcome by acting synergistically or antagonistically and thus their combined ef...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Das M,Das Bhowmik A,Bhaduri N,Sarkar K,Ghosh P,Sinha S,Ray A,Chatterjee A,Mukhopadhyay K

更新日期：2011-03-30 00:00:00

abstract：:Previous investigations have revealed sex-specific differences in brain morphometry. The effect of sex on cortical thickness may be influencing cognitive differences between sexes. With this exploratory study, we aimed to investigate the effect of sex in MRI-based cerebral cortex morphometry in healthy young volunteer...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Crespo-Facorro B,Roiz-Santiáñez R,Pérez-Iglesias R,Mata I,Rodríguez-Sánchez JM,Tordesillas-Gutiérrez D,Ortíz-García de la Foz V,Tabarés-Seisdedos R,Sánchez E,Andreasen N,Magnotta V,Vázquez-Barquero JL

更新日期：2011-03-30 00:00:00

abstract：:Neurodegenerative disorders are a subset of disabling pathologies characterized, in part, by a progressive and specific loss of certain brain cell populations. Current therapeutic approaches for the treatment of these disorders are mainly designed towards symptom management and do not manifestly block their typified n...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gibrat C,Cicchetti F

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:Evidence on antipsychotic prescribing decisions is limited. This pilot study quantified factors considered in choosing an antipsychotic and evaluated the influence of metabolic status on treatment decisions. METHODS:Prescribing decisions by 4 psychiatrists were examined based on 80 adult patients initiated ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Campbell EC,DeJesus M,Herman BK,Cuffel BJ,Sanders KN,Dodge W,Dhopesh V,Caroff SN

更新日期：2011-01-15 00:00:00